THE USE OF GELATIN-ACACIA CO-PRECIPITATE (GELAC) IN THE FORMULATION OF SUSTAINED RELEASE MATRIX TABLETS OF DICLOFENAC SODIUM
- Project Research
- 1-5 Chapters
- Abstract : Available
- Table of Content: Available
- Reference Style: APA
- Recommended for : Student Researchers
- NGN 3000
ABSTRACT
Gums find application in tablet formulation as binder because of their adhesive nature. Natural gums are promising biodegradable polymeric materials. The aim of this study was to prepare a gelatin and acacia co-precipitate (GelAc) to be used as a release retardant in the formulation of sustained release matrix Tablets of diclofenac sodium. Gelatin and acacia solution was precipitated in a ratio of 1:1 using acetone as the precipitating solvent. The dried product was size reduced and the physicochemical properties of the precipitate (GelAc) were evaluated with respect to micromeritics and Fourier Transform Infrared (FT-IR) spectroscopy. FT-IR of GelAc showed no interaction between GelAc and diclofenac. GelAc was used in varying percentages of (10 - 50 %) of the total weight of the Tablet formulation. The formulated tablets were analysed for uniformity of weight tablet thickness and diameter, crushing strength, disintegration time, friability and content uniformity. In-vitro drug release profile of diclofenac sodium from GelAc matrix tablets were also studied using Simulated Gastric Fluid (SGF) for the first two hours and Simulated Intestinal Fluid (SIF) for the next eight hours. Hydroxypropylmethylcellulose (HPMC) was used as a standard matrix to compare the sustaining action of GelAc as a drug retardant for diclofenac sodium. Result from this study showed a good yield of GelAc (92.39 %) from the Coprecipitation. GelAc also had good flow properties. The tablets produced passed the official test for Tablets and had a good content uniformity. Dissolution tests carried out showed that with an increase in GelAc concentration there was a reduction in release rate. GelAc sustained the release of diclofenac sodium for over ten hours. Tablet formulation G2 containing 20 % GelAc was considered the best as it gave the highest release co- efficient value (n) at 0.963.The result from this study shows that GelAc can be used to formulate sustained release tablets of diclofenac sodium.
Related Project Materials
THE IMPACT OF TRANSPORTATION COST ON CONSUMERS RETAIL GOODS PRICES (A CASE STUDY OF GARRIKI MARKET, ENUGU SOUTH LOCAL GOVERNMENT ENUGU STATE)
ABSTRACT
The impact of transportation cost on consumers retails goods prices (A case study of Gariki Market, Enugu South...
CHI-SQUARE TEST OF INDEPENDENCE OF STUDENTS PERFORMANCE IN UTME AND POST UTME
ABSTRACT
In chapter one, the general introduction and important definitions were well stated. In chapter two, the chi-sq...
A HYBRID GENETIC-ARTIFICIAL FISH SWARM ALGORITHM FOR ECONOMIC LOAD DISPATCH WITH VALVE-POINT AND MULTIPLE FUEL EFFECTS
ABSTRACT
The restructuring of the electrical power industry has given rise to a high degree of vibrancy and competitive...
IMPACT OF E-PAYMENT ON ONLINE SHOPPING BEHAVIOUR
Background Of The Study
The 21st century has witnessed a great exodus from the traditional busines...
SOME CARDIOVASCULAR ACTIVITIES OF THE AQUEOUS LEAF EXTRACT OF CROTON ZAMBESICUS LINN (EUPHORBIACEAE) IN LABORATORY ANIMALS
Abstract
Croton zambesicus Linn (Euphorbiaceae) is a highly valued medicinal plant in Nigeria and West African sub-region. It is used by...
AN APPRAISAL ON THE LEGAL FRAMEWORK FOR PREVENTION OF CHILD ABUSE AND TRAFFICKING IN NIGERIA
ABSTRACT
This research evaluates an appraisal on the legal framework for prevention of...
THE INFLUENCE OF YOUTH UNEMPLOYMENT ON NIGERIAN SOCIETY
BACKGROUND OF THE STUDY
It is impossible to place too much emphasis on the problem of young unemploymen...
THE RELATIONSHIP BETWEEN PEER GROUP PRESSURE AND BULLYING AMONG ADOLESCENT IN SELECTED SECONDARY SCHOOLS
ABSTRACT
This study examined the relationship between peer group pressure and bullying behavior among adolescents in sel...
INFLUENCE OF GUIDANCE PROGRAMME ON ACADEMIC ACHIEVEMENT OF SS2 STUDENTS
Abstract
Due to the importance of Guidance and counseling in the present dispensation, this study is on the influence of...
ASSESSMENT OF SKILLS ACQUISITION VIA SOCIAL MEDIA AMONG UNDERGRADUATES
Background of the study
Globally tertiary education is an instrument of for economic and human developm...
